Endocrine Abstracts

Primary aldosteronism (PHA) is one of the most common cause of secondary hypertension. It can possibly concern over 10% of hypertensive patients, but often is being under-recognised. The basic tool of case PHA detection is aldosterone to renin ratio (ARR). Appropriate cutoff value of ARR is still under discussion.We review occurrence of CT/MRI detectable adrenal gland laesions according to assigned ARR cutoff value. Retrospective data from 833 consecutiv...

Introduction: Primary hyperaldosteronism (PHA) is the most common hormonal cause of hypertension concerning about 5–12% of hypertensive individuals. Aldosterone to renin ratio (ARR) and 24 h urine aldosterone concentration (24-UAC) are important tools in PHA screening diagnostics. The most appropriate cutt off values predicting PHA are still being discussed. The study is to assess siutability and to determine optimal cut off values of ARR and 24-UAC for accurate PHA pred...

Introduction: Primary hyperaldosteronism (PHA) is the most common hormonal cause of secondary hypertensionconnected with substantially higher cardiovascular morbidity and mortality than essential hypertension (EH). The association between aldosterone excess in PHA and mutations in KCNJ5 and CACNA1D genes has been previously described and the possible relation with gene polymorphisms was to consider. The present study is to assess possible association between polymorphisms of i...